New therapeutic strategies in the resolution of ocular inflammation

Introduction
The monograph 'Inflammation: clinic and therapy' (Part I and II), published by 'l'Oculista Italiano', brings together numerous relevant scientific contributions highlighting the importance of the inflammatory component in various ocular diseases.
The two volumes describe for each pathology the current pharmacological, preventive and/or curative treatment for the therapeutic resolution of inflammation involving both the anterior and posterior segments of the eye. The efficient resolution of the inflammatory response is indicated by the successful outcome of the treatment as reflected by the protective effect of the compromised tissue, the removal of debris and dead cells and the return of damaged tissue to homeostasis (Fig. 1).

Multistep process in resolving inflammation.
Multistep process in resolving inflammation.

Fig. 1. Multistep process in the resolution of inflammation. Modified by: Recchiuti A. Resolvin D1 and its GPCRs in resolution circuits of inflammation. Prostaglandins & Other Lipid Mediators. 2013;107: 64-76. Legend: PMN: Polymorphonuclear leukocytes; M: Macrophage; MP: Plasma microparticles.

It has been further confirmed how the inflammatory process involves a complex cascade of molecular and cellular biological signals, that alter the physiological responses of the ocular tissue concerned.
The monograph also clearly shows how phlogosis is a transversal process which, when triggered by an injury event, results in particular clinical symptoms, not only confined to ocular pathologies frequently associated with inflammatory processes (e.g. allergy, conjunctivitis, keratitis, uveitis, etc.), but also, as has been demonstrated in recent years, to pathologies such as glaucoma, AMD and diabetic retinopathy.

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Indice dei contenuti

PART I - Sec. 1 - Anterior segment and phlogosis
PART I - Sec. 2 - The Uveites
Appendix I
PART II - Sec. 3 - Posterior segment and phlogosis
PART II - Sec. 4 - Tumour, traumatic and orbital inflammation
PART II - Sec. 5 - Phlogosis and surgery
PART II - Sec. 6 - Update Uveitis

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