Deficiency of LAMP2, a glycoprotein mainly expressed in the Retinal Pigmented Epithelium is associated with the onset of AMD (Age-Related Macular Degeneration). In an experiment conducted in mice, inactivation of the gene encoding for LAMP2 led to an accumulation of basal laminar deposits, typically associated with AMD and various retinal pigment epithelium dysfunctions that occur with advancing age, demonstrating the important role played by this molecule in the proper functioning of the retina. Notomi S. et al, Genetic LAMP2 deficiency accelerates the age-associated formation of basal laminar deposits in the retina. Proc Natl Acad Sci U S A. 2019;116(47):23724-23734
Individuals suffering from Chronic Inflammatory Intestinal Diseases (IBD), such as Crohn's disease and ulcerative colitis, are prone to retinal thinning. This condition appears to be due both to the autoimmune nature of MICI, in which the immune system tends to attack certain parts of the body, including the cornea, and to reduced tear production. The diagnosis of MICI should, therefore, be accompanied by thorough ophthalmological investigations to prevent possible ocular damage associated with these diseases.Czompa L. et al, Corneal Manifestations of Inflammatory Bowel Disease. Semin Ophthalmol. 2019; 34(7-8):543-550
Dr. Carmelo Chines
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