-The diagnosis of limbal stem cell deficiency. Le Q, et al. Ocul Surf. 2018 Jan;16(1):58-69. doi: 10.1016/j.jtos.2017.11.002.
Limbal stem cells (LSC) are responsible for normal homeostasis and healing of the corneal epithelium. Limbal stem cell deficiency (LSCD) is a pathological condition that results from dysfunction and/or insufficient amounts of LSCs. This review focuses on the history and recent advances in the diagnosis of LSCD.
Link: https://www.ncbi.nlm.nih.gov/pubmed/29113917
-Neuroprotective strategies for retinal disease. Pardue MT, et al. Prog Retin Eye Res. 2018 Feb 23. doi: 10.1016/j.preteyeres.2018.02.002.
A review summarising research on promising neuroprotective strategies that can promote neuronal survival in eye diseases involving vision loss and retinal cell death. Of interest is a focus on the molecules used, including bile acids, steroid hormones, and neurotrophic factors.
Link: https://www.sciencedirect.com/science/article/pii/S1350946217300848?via%3Dihub
-Epigenetics, microbiota, and intraocular inflammation: New paradigms of immune regulation in the eye. Wen X et al. Prog Retin Eye Res. 2018 Jan 17. doi: 10.1016/j.preteyeres.2018.01.001.
More and more data indicate that dysbiosis of the human microbiota leads to rapid epigenomic reprogramming of cells and results in the onset of many inflammatory diseases. In this review, we discuss how epigenetic mechanisms and the microbiota can be causative factors in ocular inflammation.
Link: https://www.sciencedirect.com/science/article/pii/S1350946217300812?via%3Dihub
-Interocular Axial Length and Corneal Power Differences as Predictors of Postoperative Refractive Outcomes after Cataract Surgery. Kansal V, et al. Ophthalmology. 2018 Feb 16. doi: 10.1016/j.ophtha.2018.01.02.1.
A retrospective cohort study conducted to determine whether differences in axial length (AL) and corneal curvature (K), as measured by optical biometry, are predictive factors of theoutcome postoperative and, therefore, whether they should be considered in preoperative planning and discussion with patients.
Link: https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(17)32500-9
-What we have learned from the Ocular Hypertension Treatment Study. Gordon MO, Kass MA. Am J Ophthalmol. 2018 Feb 28. doi: 10.1016/j.ajo.2018.02.016.
Article analysing the results of the Ocular Hypertension Treatment Study highlighting how clinicians can make evidence-based clinical decisions on ocular hypertension management using a specific risk model based on the patient's age, health status, life expectancy and personal preferences.
Link: http://www.ajo.com/article/S0002-9394(18)30074-6/fulltext
-Influence of Nasal Tear Osmolarity on Ocular Symptoms Related to Dry Eye Disease. Yi HC, et al. Am J Ophthalmol. 2018 Feb 19. doi: 10.1016/j.ajo.2018.02.008.
A prospective, cross-sectional, observational study investigating the relationship between nasal tear osmolarity and temporal characteristics of the tear film in patients with DED (Dry Eye Disease) and revealed how the difference between these components plays a crucial role in the assessment of patients with dry eye syndrome.
Link: http://www.ajo.com/article/S0002-9394(18)30066-7/fulltext
-Clinical features, imaging, and natura history of myelinated retinal nerve fibre layer. Rao R, et al. Retina. 2018 Feb 13. doi: 10.1097/IAE.0000000000002106.
This is a retrospective case series that underwent an in-depth clinical examination to document ocular and systemic characteristics in order to assess the natural history of the myelinated retinal nerve fibre layer (MRNFL) through OCT (optical coherence tomography) with enhanced depth imaging (EDI).
Link: https://insights.ovid.com/pubmed?pmid=29443798
-Histological and microRNA Signatures of Corneal Epithelium in Keratoconus. Wang YM, et al. J Refract Surg. 2018 Mar 1;34(3):201-211. doi: 10.3928/1081597X-20171215-02.
A study aimed to illustrate the histopathology of the corneal epithelium keratoconus and its regulation by micro-ribonucleic acid (miRNA). Evaluation of miRNAs and histological analysis in this study demonstrated structural and biological changes in the corneal epithelia involved, expanding the understanding of the pathology of keratoconus itself.
Link: https://www.ncbi.nlm.nih.gov/pubmed/29522231
-Recent developments in visual field testing for glaucoma. Wu Z,et al. Curr Opin Ophthalmol. 2018 Mar;29(2):141-146. doi: 10.1097/ICU.0000000000000461.
Visual field testing remains one of the most important tools for characterising and monitoring visual loss in glaucoma. This review summarises new developments in visual field testing and, in particular, standard automated perimetry.
Link: https://www.ncbi.nlm.nih.gov/pubmed/29256895
Dr. Carmelo Chines
Direttore responsabile
English 
Italian